首页|期刊导航|中华医学杂志（英文版）|Experimental study on neuroendocrinological and immunological characteristics of the military-trained artillerymen
中华医学杂志（英文版）Issue(7)：1292-1296,5.DOI:10.3760/cma.j.issn.0366-6999.2012.07.019
Experimental study on neuroendocrinological and immunological characteristics of the military-trained artillerymen
Experimental study on neuroendocrinological and immunological characteristics of the military-trained artillerymen
摘要
Abstract
Background Over one million soldiers were treated for battle- or training-fatigue during World War II.Of all groundcombat troops,37％ were discharged for psychiatric reasons due to fatigue.The neuroendocrinological and immunological systems played important roles in the work-related fatigue of military personnel.The aim of this study was to investigate the characteristics of fatigue associated with military operations,and we observed changes in the regulatory functions of the neuroendocrinological and immunological systems that may provide theoretical support for improving the combat effectiveness of armies.Methods A total of 240 soldiers from the Field Artillery regiment were selected as subjects.Researchers and subjects received training before participating in the study.Data of the subjects' medical histories,physical examinations,scores on a fatigue assessment scale,and assessments of pituitary-adrenal hormones (adrenal cortical hormone (ACTH),cortical hormone (F),and 24-hour urine-free cortisol (UFC)),pituitary-gonadal hormones (luteinizing hormone (LH),follicle-stimulating hormone (FSH),testosterone,estradiol (E2),and prolactin (PRL)),pituitary-thyroid hormones (thyroid-stimulating hormone (TSH),thyroxine (-I-r4),triiodothyronine (I-T3),free thyroxine (FT4),and free triiodothyronine (FT3)),and cellular immune parameters (CD3+,CD4+,CD8+,CD4+/CD8+,B,and NK cells) were investigated before and after large-scale and high-intensity field exercises.Data were statistically analyzed with Student's ttest using SPSS software (version 13.0),and Pvalues <0.05 were deemed to be significant.Results After the high-intensity military training,the scores on the fatigue scale reflected significant increases of feeling of unpleasantness among soldiers.Additionally,the symptom checklist showed notable increases in somatization scores and significant decreases in psychoticism scores.After intensive military work,levels of plasma ACTH,F,and UFC of soldiers were decreased (P <0.01).The level of testosterone decreased significantly after the maneuver ((23.51±6.49) versus (18.89-5.89) nmol/L; P <0.001),whereas the thyroid function (Tr3,FT4,and FT3) was markedly increased after the maneuver (P <0.01).The number of CD3+,CD4+,CD4+/CDS+ cells,and B lymphocytes were decreased (P <0.05),and NK cells were increased (P<0.001) after the maneuver.Conclusions Following high-intensity military operations,the psychological tolerance of soldiers was depressed.And the hypoadrenocorticism (the functional decreases of hypothalamic-pituitary-gonadal and abnormal pituitary-thyroid axis) contributed to the increased levels of fatigue.Hypoimmunity may increase the susceptibility to diseases after high-intensity military operations.关键词
training fatigue/military operations/endocrine hormones/immune indices/job inventoryKey words
training fatigue/military operations/endocrine hormones/immune indices/job inventory引用本文复制引用
LI Xin,HUANG Wen-xu,LU Ju-ming,YANG Guang,MA Fang-ling,LAN Ya-ting,MENG Jun-hua,DOU Jing-tao..Experimental study on neuroendocrinological and immunological characteristics of the military-trained artillerymen[J].中华医学杂志（英文版）,2012,(7):1292-1296,5.基金项目
This work was supported by a grant from the Military Medicine Research Program of General Logistics Department (No.08G 136). （No.08G 136）
