首页|期刊导航|中华医学杂志（英文版）|Biological characteristics of the cerebral venous system and its hemodynamic response to intracranial hypertension
中华医学杂志（英文版）Issue(7)：1303-1309,7.DOI:10.3760/cma.i.issn.0366-6999.2012.07.021
Biological characteristics of the cerebral venous system and its hemodynamic response to intracranial hypertension
Biological characteristics of the cerebral venous system and its hemodynamic response to intracranial hypertension
摘要
Abstract
Background The role of the cerebral venous system (CVS) in intracranial pressure (ICP) regulation remains largely unclear.In the present study,the interaction between ICP and the cerebral venous system and its possible mechanism were investigated with respect to the biological characteristics of the cerebral venous system and its hemodynamic response under increased ICP.Methods We created intracranial hypertension animal model,measured and calculated the venous flow velocity and diameter of the outflow terminal of the CVS with color ultrasonic system and recorded the vascular morphology by 3-dimensional anatomical microscopy.Patients who suffered from raised ICP underwent MRI and digital subtraction angiography (DSA) examination to show the length in the vertical direction of the wall of the bridging vein representing the diameter value.Pathological autopsy was performed from bodies of patients who had died from non-cerebral causes to observe the juncture part between the venous sinuses and tributary vertical brain veins.Results Under increased ICP conditions,venous drainage through the outlet cuff segment,a unique structure between the bridge vein and sinus,was obstructed and in turn venous blood became congested.Therefore,the increased blood volume worsened the pre-existing ICP according to the well-accepted theory regarding volume-pressure relationship.This phenomenon was described as concurrent “Venogenic intracranial hypertension”,which is characterized by intracranial venous blood stasis responsive to and together with the original increased ICP.Conclusions The existence of this special pathophysiological process is prevalent,rather than rare,in various intracranial disorders.This finding would definitely provide new insight into the area of cerebral venous system research.关键词
intracranial pressure/intracranial hypertension/cerebral veins/hemodynamics/outflow cuff segmentKey words
intracranial pressure/intracranial hypertension/cerebral veins/hemodynamics/outflow cuff segment引用本文复制引用
CHEN Jie,WANG Xi-ming,LUAN Li-ming,CHAO Bao-ting,PANG Bo,SONG Hui,PANG Qi..Biological characteristics of the cerebral venous system and its hemodynamic response to intracranial hypertension[J].中华医学杂志（英文版）,2012,(7):1303-1309,7.基金项目
This work was supported by a grant from the National Natural Science Foundation of China (No.30571917). （No.30571917）
