中华医学杂志（英文版）2012，Vol.125Issue(8)：1389-1392,4.DOI:10.3760/cma.j.issn.0366-6999.2012.08.005
Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial
Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial
GAO Jian-dong 1DING Qian 2TAN Zhi-ming 3ZHU Zhi-rong 4YUE Yun 1ZHAO Yu-jie 1XU Chen-shi 1ZHAO Jing 5HUANG Yu-guang 5WANG Tian-long 6PEI Ling 7WANG Jian 7YAO Li-nong2
作者信息
- 1. Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
- 2. Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, China
- 3. Department of Anesthesiology, Shanghai Cancer Hospital, Fudan University, Shanghai 200032, China
- 4. Department of Anesthesiology, Guangzhou Cancer Institute and ospital, Guangzhou Medical University, Guangzhou, Guangdong 10080, China
- 5. Department of Anesthesiology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China
- 6. Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
- 7. Department of Anesthesiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China
- 折叠
摘要
Abstract
Background As a new electroencephalogram (EEG) signal processing technique for monitoring the depth of anesthesia,entropy consists of two indices:reaction entropy (RE) and state entropy (SE).Our study compared entropy with classical bispectral index (BIS) in reduction of myoelectrical interference and noxious stimuli with EEG signals.Methods Two hundred and eighty patients (ASA Ⅰ-Ⅱ,18-60 years old) undergoing scheduled surgeries from seven medical centers were enrolled.Anesthesia induction was managed with propofol via the target-controlled infusion (TCI)system.The results of BIS,RE,SE,mean arterial pressure (MAP) and heart rate (HR) were recorded before anesthesia induction,at the moment of unconsciousness,before and 2 minutes after administration of muscle relaxant,and before and one and three minutes after the tracheal intubation.Results The values of half maximum effective concentrations (EC50),5％ effective concentrations (EC05) and 95％ effective concentrations (EC95) of propofol effect-site concentration at the onset of unconsciousness were 1.2 (1.1-1.3μg/ml),2.5 (2.4-2.5 μg/ml) and 3.7 (3.7-3.8 μg/ml),while those of the predicted plasma propofol concentration were 2.8 (2.7-2.9 μg/ml),3.9 (3.8-3:9 μg/ml) and 4.9 (4.8-5.0 μg/ml),respectively.The values of BIS,SE and RE were 62,59 and 63 when 50％ of patients lost consciousness,and 79,80,85 and 42,37,44,respectively,when 5％ and 95％ of patients were unconscious.The values of BIS,RE and SE dropped two minutes after the injection of muscle relaxant,but there were no significant differences between RE and SE.MAP and HR increased visibly,which indicated a reaction to tracheal intubation; the values of BIS,RE and SE,however,did not display any significant changes.Conclusions This large-sample multicentric study confirmed the values of RE and SE as approximating BIS value,at the onset of unconsciousness during propofol TCI anesthesia.After elimination of myoelectrical activation,all values of RE,SE and BIS decreased significantly and the three indices were less sensitive to noxious stimuli than cardiovascular responses.关键词
propofol/target-controlled infusion/unconsciousness/bispectral index/entropy/dose-response relationshipKey words
propofol/target-controlled infusion/unconsciousness/bispectral index/entropy/dose-response relationship引用本文复制引用
GAO Jian-dong,DING Qian,TAN Zhi-ming,ZHU Zhi-rong,YUE Yun,ZHAO Yu-jie,XU Chen-shi,ZHAO Jing,HUANG Yu-guang,WANG Tian-long,PEI Ling,WANG Jian,YAO Li-nong..Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial[J].中华医学杂志（英文版）,2012,125(8):1389-1392,4.
