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Review of clinical investigation on recurrence of gastric cancer following curative resection

LI Jing-hui ZHANG Shi-wu LIU Jing SHAO Ming-zhe CHEN Lin

中华医学杂志(英文版)2012,Vol.125Issue(8):1479-1495,17.
中华医学杂志(英文版)2012,Vol.125Issue(8):1479-1495,17.DOI:10.3760/cma.j.issn.0366-6999.2012.08.022

Review of clinical investigation on recurrence of gastric cancer following curative resection

Review of clinical investigation on recurrence of gastric cancer following curative resection

LI Jing-hui 1ZHANG Shi-wu 2LIU Jing 3SHAO Ming-zhe 4CHEN Lin3

作者信息

  • 1. Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China
  • 2. School of Medicine, Nankai University, Tianjin 300071, China(Li JH, Zhang SW, Liu J,Shao MZ and Chen L)
  • 3. Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China
  • 4. School of Medicine, Nankai University, Tianjin 300071, China
  • 折叠

摘要

Abstract

Objective To discuss the present status and progress of clinical research on recurrence of gastric cancer after surgery,including patterns,clinicopathologic factors,prognosis,detection,diagnosis,prevention,and treatment strategies.Data sources The data used in this review were mainly from PubMed articles published in English from 2000 to August 2011.The search terms were “gastric cancer” and “recurrence”.Study selection Articles were selected if they involved clinicopathologic factors,detection methods,and treatment strategies of recurrence of gastric cancer.Results Peritoneal recurrence is the most common pattern in recurrence of gastric cancer.The main risk factors for recurrence of gastric cancer are tumor stage,including depth of tumor invasion and lymph node metastasis,and Borrmann classification.The prognosis of patients with recurrence is very poor,especially patients with peritoneal recurrence.Systemic chemotherapy is still the main treatment method for patients with recurrent cancer.If complete resection can be accomplished,some benefits may be obtained from surgery for recurrence.However,standard treatment for patients with recurrence has not yet been established.Conclusions Early detection and diagnosis of recurrence is quite crucial for treatment and prognosis.The optimal therapeutic strategy for recurrence should be based on a multidisciplinary assessment and the patient's individual state and should involve combined therapy.

关键词

recurrence/gastric cancer/locoregional recurrence/peritoneal recurrence/treatment

Key words

recurrence/gastric cancer/locoregional recurrence/peritoneal recurrence/treatment

引用本文复制引用

LI Jing-hui,ZHANG Shi-wu,LIU Jing,SHAO Ming-zhe,CHEN Lin..Review of clinical investigation on recurrence of gastric cancer following curative resection[J].中华医学杂志(英文版),2012,125(8):1479-1495,17.

基金项目

This study was supported by the National Natural Science Foundation of China (No.81172368) and the Capital Clinical Application Research Foundation (No.Z111107058811047). (No.81172368)

中华医学杂志(英文版)

OACSCDCSTPCDMEDLINESCI

0366-6999

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