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Association between the eNOS gene polymorphisms and rheumatoid arthritis risk in a northern Chinese population

AN Jin-dan LI Xin-yuan YU Jian-bo ZHAO Yu JIN Zai-shun

中华医学杂志（英文版）2012，Vol.125Issue(8)：1496-1499,4.

中华医学杂志（英文版）2012，Vol.125Issue(8)：1496-1499,4.DOI:10.3760/cma.j.issn.0366-6999.2012.08.023

Association between the eNOS gene polymorphisms and rheumatoid arthritis risk in a northern Chinese population

AN Jin-dan ¹LI Xin-yuan ²YU Jian-bo ³ZHAO Yu ¹JIN Zai-shun⁴

作者信息

1. Department of Pathology, Basic Medical College
2. Key Laboratory of Cancer Prevention and Treatment of Heilongjiang Province
3. Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China Department of Rheumatism and Immunology, the Second Affiliated Hospital of Harbin Medical University, Harbin,Heilongjiang 150081, China
4. Department of Laboratory Diagnosis, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China(Zhao Y)
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摘要

Abstract

Background Several genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene are associated with the pathogenesis of rheumatoid arthritis (RA).The objective of the present study was to investigate whether the two SNPs (T-786C and G894T) of the eNOS gene are associated with rheumatoid arthritis risk in a northern Chinese population.Methods In this study,the eNOS genes T-786C and G894T were studied in 196 cases with rheumatoid arthritis and 201 healthy controls with gender,age and ethnicity matched.The two SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).The analyses of association were statistically compared using the chi-square test with SPSS software for Windows.Results The frequency of the -786C allele was significantly higher in the rheumatoid arthritis patients than in the healthy controls (19.64％ vs.14.18％,P ＜0.05).However,the 894T allele of the eNOS gene was not increased in the rheumatoid arthritis patients compared to the healthy controls.Conclusions Individuals with the -786CC genotype have an increased risk of rheumatoid arthritis.Further study with an increased samole size is necessary for the studv of the role of this SNP in rheumatoid arthritis.

关键词

endothelial nitric oxide synthase/rheumatoid arthritis/polymorphisms

Key words

endothelial nitric oxide synthase/rheumatoid arthritis/polymorphisms

引用本文复制引用

AN Jin-dan,LI Xin-yuan,YU Jian-bo,ZHAO Yu,JIN Zai-shun..Association between the eNOS gene polymorphisms and rheumatoid arthritis risk in a northern Chinese population[J].中华医学杂志（英文版）,2012,125(8):1496-1499,4.

基金项目

This study was supported by Heilongjiang Province Science Foundation for Key Programs (No.LC06C25). （No.LC06C25）

中华医学杂志（英文版）

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ISSN：0366-6999

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