中华医学杂志（英文版）2012，Vol.125Issue(9)：1669-1671,3.DOI:10.3760/cma.j.issn.0366-6999.2012.09.029
Infusions of recipient-derived cytokine-induced killer cells of donor origin eradicated residual disease in a relapsed leukemia patient after allo-hematopoietic stem cell transplantation
Infusions of recipient-derived cytokine-induced killer cells of donor origin eradicated residual disease in a relapsed leukemia patient after allo-hematopoietic stem cell transplantation
ZHONG Zhao-dong 1LUO Yi 1ZOU Ping 1ZHENG Jin-e 2YAO Jun-xia 2HUANG Shi-ang 2ZHOU Dong-feng 3YOU Yong1
作者信息
- 1. Department of Hematology,Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
- 2. Center for Stem Cell Research and Application, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
- 3. Department of Pediatric Hematology,Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
- 折叠
摘要
Abstract
A female patient diagnosed with acute myelocytic leukemia M5a (AML-M5a) relapsed 986 days after her allogeneic peripheral blood stem cell transplantation (allo-PBSCT) from an unrelated male donor with matched human leukocyte antigen (HLA).Three re-induction chemotherapies were administered,and partial remission was achieved.The patient was given repetitive infusion of cytokine-induced killer (CIK) cells expanded from recipient peripheral mononuclear cells of full donor chimerism due to loss of contact of quondam donor for donor lymphocyte infusion (DLI) and rejection of second transplantation.The patient achieved complete cytogenetical remission.This strategy might overcome the obstacle of donor unavailability and present an appealing new therapeutic alternative to donor-recruited adoptive immunotherapy for relapsed disease at post-transplantation.关键词
cytokine-induced killer cells/stem cell transplantation/relapsed leukemia/minor residual disease/donor lymphocyte infusionKey words
cytokine-induced killer cells/stem cell transplantation/relapsed leukemia/minor residual disease/donor lymphocyte infusion引用本文复制引用
ZHONG Zhao-dong,LUO Yi,ZOU Ping,ZHENG Jin-e,YAO Jun-xia,HUANG Shi-ang,ZHOU Dong-feng,YOU Yong..Infusions of recipient-derived cytokine-induced killer cells of donor origin eradicated residual disease in a relapsed leukemia patient after allo-hematopoietic stem cell transplantation[J].中华医学杂志（英文版）,2012,125(9):1669-1671,3.
