浙江医学2012，Vol.34Issue(11)：878-881,4.
丙戊酸钠对博莱霉素致肺纤维化大鼠TNF-α表达的影响
Valproate modulated the expression of TNF-α in mice with bleomycin-induced pulmonary fibrosis
黄旭晴 1李万成 1李旭 1陈刚1
作者信息
- 1. 310015,杭州师范大学附属医院呼吸科
- 折叠
摘要
Abstract
Objective To explore the effects of valproate, a histone deacetylase inhibitor (HDACI Jon the expression of TNF-α in mice with bleomycin-induced(BLM ) pulmonary fibrosis(PF). Methods Fifty-four SD mice were randomly divided into three groups (18 rats each group ),ie. a control group (CG), a bleomycin-induced pulmonary fibrosis model group (MG) and a sodium valproate-treated group(VG). Results It was founded that the hydroxyproline contents and Szapiel scores, the expression of TNF-α in MG and VG group were greatly increased, especially in MG group. However, the expression of TNF-α, the hydroxyproline contents and Szapiel scores in VG group were lower than those in MG group. Conclusion This study indicates that administration of valproate to the mice suffered from pulmonary fibrosis induced by bleomycin attenuates the fibrosis via inhibiting early inflammation.关键词
组蛋白脱乙酰基转移酶抑制剂/肺间质纤维化/肿瘤坏死因子-αKey words
Histone deacetylase inhibitor(HDACI)/ Pulmonary interstitial fibrosis/ TNF-α引用本文复制引用
黄旭晴,李万成,李旭,陈刚..丙戊酸钠对博莱霉素致肺纤维化大鼠TNF-α表达的影响[J].浙江医学,2012,34(11):878-881,4.
