浙江医学2012，Vol.34Issue(12)：993-995,3.
脑膜瘤PR、ER、AR、p53、Ki-67、MYC、VEGF检测的临床意义
Expression of progesterone receptor, estrogen receptor, androgen receptor, Ki-67, p53, MYC, and vascular endothelial growth factor in meningioma tissue
摘要
Abstract
Objective To determine the expressions of progesterone receptor (PR), estrogen receptor (ER), androgen receptor (AR),P53,Ki-67, MYC and vascular endothelial growth factor (VEGF) in human meningioma tissue and to investigate its significance. Methods The expressions of PR,ER,p53,AR,Ki-67,MYC and VEGF were detected on microarrays by Immunohis-tochemistry in 64 tissue specimens of meningioma. Results The expressions of PR,VEGE,p53,Ki-67 and MYC proteins were correlated with the malignancy degree of meningioma (P<0.05 or P<0.01). There were significant differences in expression rates of PR,AR,p53,Ki-67and MYC between recurrent and nonrecurrent meningioma (P<0.01 or P<0.05). Conclusion Meningioma with high expression of p53, Ki—67, MYC and negative expression of PR shows high degree of malignancy and is more likely to relapse.关键词
脑膜瘤/孕酮受体/P53/Ki-67/MYCKey words
Meningioma/ Progesterone receptor/ p53/ Ki-67/ MYC引用本文复制引用
顾云彪,周涛..脑膜瘤PR、ER、AR、p53、Ki-67、MYC、VEGF检测的临床意义[J].浙江医学,2012,34(12):993-995,3.基金项目
临海市科技计划项目(062KY07) （062KY07）
