浙江医学2012，Vol.34Issue(12)：999-1001,3.
早期肠内营养对急性重型颅脑损伤患者血清C反应蛋白浓度的影响
Plasma C-reactive protein levels in patients with acute severe brain injury undergoing early enteral nutrition
摘要
Abstract
Objective To investigate plasma C-reactive protein (CRP) levels in patients with acute severe brain injury undergoing early enteral nutrition (EEN). Methods One hundred and twenty patients with acute severe brain injury were randomly divided into EEN group and early parenteral nutrition (PN) group. The nutrition support was given to all the patients within 48h after admission to the hospital. Thirty healthy subjects served and normal controls. Sequential serum CRP levels were measured by rate nephenometry in normal control and patients at 6h, 2, 4, 6 , 8 and 14d after the injury. Results Serum CRP levels in brain injury patients were significantly higher than those of normal controls (P<0.05); in patients serum CRP levels reached to the peak value in 2d after injury, then gradually decreased. Serum CRP levels were significantly lower in the EEN group at 4, 6, 8 and 14 d after injury than those in PN group at the same time points (P<0.05 or P<0.01). Conclusion The serum CRP levels are elevated significantly after acute severe brain injuries. EEN can decrease CRP levels, which indicates that it may protect the gastro-intestinal mucous membrane and reduce systemic inflammatory reaction in patients with acute severe brain injury.关键词
早期肠内营养/急性重型颅脑损伤/C反应蛋白Key words
Early enteral nutrion/ Acute severe brain injury/ C-reactive protein引用本文复制引用
周央环,陈再丰..早期肠内营养对急性重型颅脑损伤患者血清C反应蛋白浓度的影响[J].浙江医学,2012,34(12):999-1001,3.基金项目
浙江省卫生厅科技计划项目(2010KYA176) （2010KYA176）
