中山大学学报（自然科学版）2012，Vol.51Issue(2)：59-62,4.
一株红树内生真菌Nigrospora sp.中次级代谢产物及其细胞毒活性研究
Research on the Secondary Metabolites and Their Cytotoxic Activity of Mangrove Endophytic Fungus Nigrospora sp.from the South China Sea
摘要
Abstract
Research on the secondary metabolites of the mangrove endophytic fungus Nigrospora sp. From the South China Sea was reported. Three secondary metabolites were isolated from the ethyl acetate extract of the fermentation by silica gel column chromatography, preparative thin layer chromatography and recrystallgraphy. Their structures were identified by comprehensive spectroscopic methods as Griseofulvin (1), Vermixocin B (2) , Tenellic acid A (3). The absolute configuration of compound 1 was further confirmed by single-crystal X-ray analysis. The cytotoxic activity of compound 1 in vitro was also evaluated, and compound 1 showed medium activity against KB, KBV200, and A549 cell lines with IC50 of 8. 23, 9. 10 and 14. 26 μmol/L, respectively.关键词
红树林内生真菌/次级代谢产物/细胞毒活性/单晶X-rayKey words
mangrove endophytic fungus/ secondary metabolites/ cytotoxic activity/ X-ray diffraction分类
化学引用本文复制引用
魏美燕,李尚德,袁宁宁,梁丽萍,佘志刚,林永成..一株红树内生真菌Nigrospora sp.中次级代谢产物及其细胞毒活性研究[J].中山大学学报（自然科学版）,2012,51(2):59-62,4.基金项目
国家自然科学基金资助项目(20972197) （20972197）
广东医学院面上基金资助项目(M2010002) （M2010002）
海洋药物教育部重点实验室开放基金资助项目(KLMD (OUC) 2008-1) （KLMD (OUC）
