中山大学学报（医学科学版）2012，Vol.33Issue(2)：178-183,6.
幼猪体外循环期间应用氟碳化合物乳剂对肺气体交换的影响
Effect of Perflurocarbon Emulsion during Cardiopulmonary Bypass on Pulmonary Oxygenation Function in Piglets
摘要
Abstract
[Objective] To observe the effect of partial liquid ventilation (PLV) during cardiopulmonary bypass on gas exchange and histopathological changes of lung. [Methods] After cardiopulmonary bypass (CPB) was established, eighteen piglets were assigned randomly into 3 groups. Group I (Control Group): Animals in control group received no treatment but conventional mechanical ventilation; Group U ; 5 mL/kg Oxygent· Was instilled into the trachea during CPB; Group Ⅲ : 15 mL/kg Oxygent·was instilled into the trachea during CPB. The changes of gas exchange and lung compliance were examined before CPB, 5 min, 0.5 h, 1, 1.5, and 2 h after withdraw of CPB. Histological sections were taken from right downsides of lung and stained by H&E. [ Results ] The P,,o, significantly increased and alveolar-arterial oxygen gradient (AaDOj) markedly decreased in low dose PLV group (group Ⅱ ) compare with control group (group I ) and large dose group (group Ⅲ ) (P<0.05) at the time of 0.5, 1, 1.5, and 2 h post-CPB. The histopathological lesions of lung were less severe in low dose PLV group (group Ⅱ) compare with control group and large dose group (group Ⅲ ). [Conclusion] Partial liquid ventilation during CPB with low dose Oxygent· Can improve the oxygenation of lung and increase the Pa,O2 after CPB.关键词
部分液体通气/氟碳化合物/体外循环/肺损伤Key words
partial liquid ventilation/ perflurocarbon/ cardiopulmonary bypass/ lung injury分类
医药卫生引用本文复制引用
王晟,曾嵘,黄卫,郭晓纲..幼猪体外循环期间应用氟碳化合物乳剂对肺气体交换的影响[J].中山大学学报（医学科学版）,2012,33(2):178-183,6.基金项目
国家自然科学基金(30801077) （30801077）
广东省科技计划项目(2009B030801033,2008B030301169) （2009B030801033,2008B030301169）
