中山大学学报（医学科学版）2012，Vol.33Issue(2)：260-264,5.
胸上段食管癌容积旋转调强和静态调强与三维适形放疗计划的剂量学比较
Volumetric Modulated Arc Therapy, Conventional Intensity-modulated Radiotherapy and Three-Dimensional Conformal Techniques for Upper Thoracic Esophageal Cancer: A Planning Comparison Study
摘要
Abstract
[Objective] A planning study was performed to compare volumetric modulated arc therapy (VMAT), static intensity-modulated radiotherapy (sIMRT), and three-dimensional conformal radiotherapy (3DCRT) for upper thoracic esophageal cancer. [Methods] Seven patients with loco-regionally advanced upper thoracic esophageal cancer were included. Based on the identical CT and planning target volume (PTV), three plans (3DCRT, sIMRT with seven fields, VMAT with a single arc) were generated. Dose prescription was set to 60Gy in 30 fractions. Dose volume histograms, MU and delivery time were evaluated to assess plan quality. [Results] In comparison to 3DCRT, both VMAT and IMRT provided a systematic improvement in PTV coverage. For normal tissues, equivalent sparing of lung and heart were achieved with three plans. However, IMRT and VMAT showed a superior sparing compared with 3DCRT for spinal cord. The MU/fraction was as follows; 537 ± 92 for 3DCRT, 601 ± 122 for IMRT, and 682 ± 139 for VMAT. Effective treatment time for 3DCRT, IMRT and VMAT were (3.9 ± 0.3) min, (6.0 ± 0.7) min and (4.7 ± 0.7)min, respectively (P< 0.05). [Conclusions] Compared with 3DCRT, IMRT and VMAT showed better dosimetric quality and superior spinal cord sparing. However, VMAT improved delivery efficiency significantly than IMRT.关键词
放射治疗/食管肿瘤/容积旋转调强/静态调强/剂量学Key words
radiotherapy/ esophageal neoplasm/ volumetric modulated arc therapy/intensity-modulated radiotherapy/ dosimetry分类
医药卫生引用本文复制引用
张瑞,习勉,李巧巧,赵磊,黄晓波,何立儒,胡永红,刘孟忠..胸上段食管癌容积旋转调强和静态调强与三维适形放疗计划的剂量学比较[J].中山大学学报（医学科学版）,2012,33(2):260-264,5.基金项目
广东省医学科研基金(B2011114) （B2011114）
