中国中西医结合杂志2012，Vol.32Issue(3)：322-324,328,4.
慢性胃炎脾胃湿热证与外周血Th1/Th2平衡的研究
Study of Th1/Th2 Balance in Perlpheral Blood of Chronlc Gastritis Patients with Pl-Wei Damp-Heat Syndrome
摘要
Abstract
Objective To study the correlation between the Th1/Th2 balance in the peripheral blood and Pi-Wei damp-heat syndrome (PDS) in chronic gastritis (CG). Methods Fifty-one patients with CG of POS were recruited, including 22 cases with predominant damp (PDS-D), 9 case with predominant heat (PDS-H), and 20 case with simultaneous onset of damp and Heat (PDS-DH). Besides, 10 healthy volunteers were recruited as the healthy control group. H. Pylori (HP) infection was detected by fast urea enzyme, and the expressions of Th1 type cytokines interferon-y (IFN-y), interieukin-12 (IL-12), and Th2 type cytokines interieukin-4 (IL-4), in-terleukin-10 (IL-10) in serum were detected by luminex technology. Results The HP infection rate was 41.18% (21/51) in the PDS patients, obviously higher than that in the healthy control group (10. 00% ,1/10), showing statistical difference (P < 0. 05). The HP infection rate was 45.45% (10/22) in PDS-D, 22. 22% (2/9) in PDS-H, and 45.00% (9/20) in PDS-DH. The HP infection rate in PDS-D and PDS-DH was significantly higher than that of the healthy control group, showing statistical difference (P<0. 05). There was no statistically significant difference in the expressions of peripheral blood IFN-y, IL-12, IL-4, and IL-10 between the PDS patient group and the healthy control group (P>0. 05). But the expressions of IFN-y and IL-12 showed an increasing trend in the PDS patient group, while the expression of IL-4 showed a decreasing trend. The expressions of IFN-y, IL-12, IL-4, and the ratios of IFN-y/IL-4 and IL-12/IL-4 were also higher in PDS-DH group than in the PDS-D group and the PDS-H group, but with no statistical significance (P>0. 05). Conclusion The occurrence of Pi-Wei damp-heat CG was possibly correlated with the imbalance of Th1/Th2. Damp and heat pathogen might be important pathogenic factors leading to Th1 type cytokine immunoreaction.关键词
慢性胃炎/脾胃湿热证/Th1/Th2平衡Key words
chronic gastritis/Pi-Wei damp-heat syndrome/the balance of Th1/Th2引用本文复制引用
梁嘉恺,胡玲,郑晓凤,鄢雪辉,古文莉..慢性胃炎脾胃湿热证与外周血Th1/Th2平衡的研究[J].中国中西医结合杂志,2012,32(3):322-324,328,4.基金项目
国家自然科学基金资助项目(No.30772689) （No.30772689）
广东省自然科学基金资助项目(No.7004802) （No.7004802）
