中国中西医结合杂志2012，Vol.32Issue(3)：348-351,4.
参附注射液治疗严重脓毒症临床疗效及对血清IL-6、IL-10水平的影响
Clinical Efficacy of Shenfu Injection in Treating Severe Sepsis and Its Effects on Serum Levels of Interleukin-6 and Interleukin-10
摘要
Abstract
Objective To observe the therapeutic efficacy of Shenfu Injection (SFI) on patients with severe sepsis and its effects on serum levels of interleukin-6 (IL-6) and interleukin-10 (IL-10). Methods Sixty-eight patients with severe sepsis were randomly assigned to the SFI group (36 cases, treated by SFI + routine therapy) and the control group (32 cases, treated by routine therapy). The acute physiology and chronic health evaluation II (APACHE ||) score and Marshall score were observed before treatment, 3 and 7days after treatment. The therapeutic efficacy was assessed, and the 28th-day mortality rates were compared. The serum levels of IL-6 and IL-10 were determined by enzyme-labeled immunosorbent assay (ELISA) before and after treatment. C-reactive protein (CRP) was determined by immunoturbidimetric assay. Results There was no significant difference in the APACHE || score, Marshall score, IL-6, IL-10, or CRP between the two groups before treatment (P >0. 05). APACHE || score and Marshall score of all patients decreased after treatment, with more obvious decrease shown in the SFI group (P<0. 05). The mortality rate in the SFI group and the control group was 25. 0% (9/36) and 37. 5% (12/32) respectively, with no significant difference shown between the two groups (P > 0. 05). The serum levels of IL- 6 and CRP obviously decreased after 7 days of treatment (P < 0. 05). But more decrement was shown in the SFI group, showing significant difference when compared with the control group (P<0. 05). There was no significant difference in the serum IL-10 level between the two groups before and after treatment (P>0.05). Conclusion SFI could lower the serum IL-6 level, regulate the equilibrium of proinflammatory factors and anti-inflammatory cytokines in severe sepsis patients, thus playing a role in improvingthe therapeutic efficacy.关键词
严重脓毒症/参附注射液/白细胞介素/C反应蛋白/急性生理学与慢性健康状况评分系统/Marshall评分Key words
severe sepsis/Shenfu Injection/interleukin/C reactive protein/acute physiology and chronic health evaluation II/Marshall score引用本文复制引用
邱泽亮,叶一萍,张宁,刘建华..参附注射液治疗严重脓毒症临床疗效及对血清IL-6、IL-10水平的影响[J].中国中西医结合杂志,2012,32(3):348-351,4.基金项目
浙江省中医药科技计划资助项目(No.2009CB084) （No.2009CB084）
