中国中西医结合杂志2012，Vol.32Issue(3)：371-374,4.
养肝益水颗粒对自发性高血压大鼠血浆AngⅡ、TGF-β1、CTGF含量和肾皮质AngⅡ、TGF-β1、CTGF mRNA表达的影响
Effect of Yanggan Yishui Granule on Plasma Ang Ⅱ, TGF-β1, CTGF Content, and Renal Cortical AngⅡ, TGF-β1, and CTGF mRNA Expressions in Spontaneously Hypertensive Rats
摘要
Abstract
Objective To study the effect of Yanggan Yishui Granule (YGYSG) on 12-week-old spontaneously hypertensive rats (SHR) on plasma angiotensin II (Ang II ), transforming growth factor p, (TGF-p,), connective tissue growth factor (CTGF) content and renal cortical Ang II , TGF-p,, CTGF mRNA expressions, and to further explore the mechanism of YGYSG in the kidney protection. Methods Forty 12-week-old male SHR were randomized into the model group, the Bella Plymouth group (at the daily dose of 1. 8 mg/kg), the YGYSG low dose group (at the daily dose of 5.4 g/kg), and the YGYSG high dose group (at the daily dose of 27 g/kg), 10 in each group. Another ten Wistar-Kyoto (WKY) rats were included as the control group. Equal volume of normal saline was given to SHR by gastrogavage in the model group and the normal control group, once a day for six weeks. The plasma Ang II, TGF-p, and CTGF concentrations, and the renal cortical Ang II, TGF-p,, CTGF mRNA expressions were measured in each group. Results Bella Plymouth was superior to YGYSG in reducing plasma Ang II , TGF-p, and CTGF, while the high and low dose YGYSG showed no significant difference (P>0. 05). In reducing plasma Ang II , TGF-p, and CTGF mRNA expressions, low doses YGYSG was similar to the role of Bella Plymouth, and the role of high dose YGYSG was superior to low dose YGYSG and Bella Plymouth. Conclusion YGYSG played a role in kidney protection mainly through reducing theAng ||, TGF-p, and CTGF expressions of kidney.关键词
养肝益水颗粒/自发性高血压大鼠/血管紧张素Ⅱ/转化生长因子β1/结缔组织生长因子Key words
Yanggan Yishui Granule/spontaneously hypertensive rat/angiotensin ||/transforming growth factor p/connective tissue growth factor引用本文复制引用
戴小华,王波,杨帆,董梅,许祖建,邵正斌,顾健霞,周宜轩..养肝益水颗粒对自发性高血压大鼠血浆AngⅡ、TGF-β1、CTGF含量和肾皮质AngⅡ、TGF-β1、CTGF mRNA表达的影响[J].中国中西医结合杂志,2012,32(3):371-374,4.基金项目
安徽省自然科学基金资助项目(No.090413254) （No.090413254）
