中医药信息2012，Vol.29Issue(2)：39-42,4.
洋参御糖丸对STZ-DM模型大鼠肝脏结构影响的实验研究
Effect of YTW on the Liver Organization Structure in 2DM Animal Models Induced by STZ and High Fat Diet
摘要
Abstract
Objective: To investigate the effect of YTW on the liver structure changes of 2DM rats in model group and different treatment groups. Methods; Wistar male rats were 100, including 12 in the control group which were given free water intake. The model group (including 88 rats) with high sugar and high fat diet were given the injection of STZ in abdominal cavity for four weeks later. At last we selected the successful modeling and blood glucose levels close to 75 rats. Then they were divided into five groups stochastically (each group of 15 rats): model group (M), YU Di group (YD) , YU Gao group (YG), Zhong Dui group ( Zd - Liu Wei Di Huang Wan) , Xi Dui group ( Xd - metformin). At the end of the experiment, pathological section of all rats' liver were made and stained by light microscope and electric mirror for observation. Result; Compared with normal control group ( K), to some extent, liver structure has different changes after treatment , especially excellence in high dose of YG group. That could be seen in two treatment groups ( YD, YG) , in which rats'liver structure had been affected. Conclusion; Copied STZ in diabetic rats and high fat diet , and different liver damages of rats have been seen in groups. It can be concluded that YTW can alleviate the 2DM rats' liver structure damages obviously after treatment, that is, YTW has a certain therapeutic function on diabetic animal models.关键词
洋参御糖丸/STZ/高脂饮食/糖尿病/肝脏Key words
Yangshen Yutang pills/STZ/High fat diet/Diabetes mellitus/Liver分类
医药卫生引用本文复制引用
谢宁,张良..洋参御糖丸对STZ-DM模型大鼠肝脏结构影响的实验研究[J].中医药信息,2012,29(2):39-42,4.基金项目
黑龙江省研究生创新科研基金项目(YJSCX2011-430HLJ) （YJSCX2011-430HLJ）
教育部春晖计划资助项目(5030411) （5030411）
