北京师范大学学报：自然科学版2012，Vol.48Issue(3)：266-269,4.
熊果酸抑制脂肪酸合酶及诱导HepG2细胞凋亡机制研究
URSOLIC ACID INDUCED HEPG2 CELLS APOPTOSIS VIA INHIBITING FATTY ACID SYNTHASE
摘要
Abstract
The widely present plant chemical ursolic acid（UA） has important anti-cancer activity.UA is a natural inhibitor of fatty acid synthase（FAS） which is highly expressed in cancer cells.It was found in MTT assay that UA inhibited cell growth with an IC50 of 68.23 μmol·L-1.Hoechst 33258 fluorescence microscopy revealed that UA induced apoptosis in HepG2 cells dose-dependently.UA addition reduced significantly FAS expression.After sodium palmitate addition to cells incubated with UA,cellular viability was restored.It is concluded that tumor suppression activity of UA is due to its inhibitory activity against tumour cell FAS,leading to blockade of fatty acid synthesis.The lack of fatty acids for cellular metabolism triggers cancer cell apoptosis.关键词
脂肪酸合酶/熊果酸/HepG2细胞/细胞凋亡Key words
fatty acid synthase/ursolic acid/HepG2 cells/apoptosis分类
生物科学引用本文复制引用
樊慧锦,田维熙,马晓丰..熊果酸抑制脂肪酸合酶及诱导HepG2细胞凋亡机制研究[J].北京师范大学学报：自然科学版,2012,48(3):266-269,4.基金项目
中国科学院生命科学领域优秀青年科技专项基金资助项目 （）
中国科学院十二五知识创新工程重要方向资助项目 （）
中国科学院研究生院院长基金资助项目 （）
王宽诚教育基金会资助项目 （）
