重庆医学2012，Vol.41Issue(19)：1923-1925,3.DOI:10.3969/j.issn.1671-8348.2012.19.010
氟比洛芬酯对两种不同靶浓度瑞芬太尼输注下七氟醚MACBAR的影响
Effects of flurbiprofen axetil on sevoflurane MACBAR at two target-controlled concentrations of remifentanil
李红波 1林雷 2陈春 2严蕾1
作者信息
- 1. 湖北省远安县人民医院麻醉科,444200
- 2. 三峡大学第一临床医学院麻醉科,443003
- 折叠
摘要
Abstract
Objective To determine the effects of flurbiprofen axetil on the sevoflurane requirement for blunting adrenergic responses following surgical incision when sevoflurane combined with two different target-controlled concentrations of remifentanil (1 and 3 ng/mL). Methods A total of 76 patients, scheduled to undergoing general anaesthesia for elective abdominal surgery, were randomly allocated to receive sevoflurane anaesthesia alone (group A,n = 41),or with the addition of flurbiprofen (group F,n = 35). Patients of both groups were further assigned to receive a target-controlled effect-site concentration of 1 ng/mL (group A1, n = 24;group Fl,n = 21),or 3 ng/mL remifentanil (group A3 ,n = 17 ;group F3,n=14). Predetermined end-tidal sevoflurane con-centrations and minimum alveolar concentration (MAC) for each group were determined using an up-and-down sequential allocation technique. Results All patients completed the study. The MAC of sevoflurane were 2. 03% [95% confidence interval(95%CD : 1. 9%-2. 1%] in group Al and 1. 65%(95%CI:1. 5%- 1. 9%)in group F1 (P<0. 01) , group F1 reduced it by 18. 8% than group A1;while in groups A3 and F3 the MAC of sevoflurane were 0. 4%(95%CI:0. 2%-0. 6%)and 0. 35%(95%CI:0. 2%-0. 4%) , respectively (P>0. 05) ,group P3 reduces by 12. 5%. Conclusion The addition of flurbiprofen axetil reduces the MAC of sevoflurane by 18. 8% when using a remifentanil concentration of 1 ng/mL,and reduces 12. 5% when using a remifentanil concentration of 3 ng/mL.关键词
氟比洛芬酯/七氟醚/肺泡最小有效浓度/瑞芬太尼/肾上腺素能反应Key words
flurbiprofen axetil/sevoflurane/minimum alveolar concentration/remifentanil/adrenergic response引用本文复制引用
李红波,林雷,陈春,严蕾..氟比洛芬酯对两种不同靶浓度瑞芬太尼输注下七氟醚MACBAR的影响[J].重庆医学,2012,41(19):1923-1925,3.
