摘要
Abstract
Objective To determine the effects of gastrodin on postoperative cognitive dysfunction(POCD) in patients undergo cardiopulmonary bypass. Methods A total of 120 patients, scheduled to undergo cardiopulmonary bypass for cardiac surgery, were randomly allocated to receive gastrodin(experiental group,n = 60) ,and saline(control group,n = 60). The incidence of POCD at pre-surgery, 3 days post-surgery, 7 days post-surgery, 10 weeks post-surgery and 6 months after surgery were assessed by MMSE. Mor-bidity and length of stay were recorded. Results The incidence of POCD at pre-surgery,3 days post-surgery, 7 days post-surgery, 10 weeks post-surgery and 6 months after surgery in experiental group was 26. 7 % , 11. 7 % , 5. 1 % , 1. 8 % , respectively. The inci-dence of POCD in control group was 45% , 20% , 7% , 1. 9%, respectively. The incidence of neurocognitive dysfunction at 3 days post-surgery was significantly lower for gastrodin compared with saline(P<0. 05). There were no differences in morbidity and length of stay. Conclusion Gastrodin may contribute to early cognitive recovery after open-heart surgery with cardiopulmonary bypass, but has no effect on the incidence of long-term POCD.关键词
天麻素/体外循环/术后认知功能障碍Key words
gastrodin/extracorporeal circulation/postoperative cognitive dysfunction.
