儿科药学杂志2012，Vol.18Issue(6)：38-40,3.
年龄性别对癫痫患儿奥卡西平活性代谢物血药浓度的影响分析
Analysis of the Influencing Factors of the Plasma Concentration of Oxcarbazepine Active Metabolite in Children with Epilepsy
林志燕 1刘海涛 1舒扬 1王芳 1田怀平 1徐阿晶1
作者信息
- 1. 上海交通大学医学院附属新华医院,上海200092
- 折叠
摘要
Abstract
Objective:To study the (actors which affect the blood concentration of the metabolite of oxcarbazepine ( MHD) in children. Methods: Totally 217 children with epilepsy were collected from our hospital; each of them was treated by oxcarbazepine. The concentration of active metabolite was detected by high-performance liquid chromatngraphy (HPLC) method. Results: In recommended dose, the concentration of MHD had a tendency to increase with age, but showing no significant difference ( P>0. 05); in some conditions, the concentration of MHD had no significant difference in different gender groups (P>0. OS). Conclusions: In recommended dose, the concentration of MHD had a tendency to increase with age, and had no correlation with gender. So the concentration of MHD should be monitored regularly, in order to adjust the dosage timely and realize the personalized medicine.关键词
奥卡西平/代谢产物/血药浓度/癫痫/儿童Key words
Oxcarbazepine/ Metabolite/ Plasma concentration/ Epilepsy/ Children分类
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林志燕,刘海涛,舒扬,王芳,田怀平,徐阿晶..年龄性别对癫痫患儿奥卡西平活性代谢物血药浓度的影响分析[J].儿科药学杂志,2012,18(6):38-40,3.
