高等学校化学学报2012，Vol.33Issue(5)：958-963,6.DOI:10.3969/j.issn.0251-0790.2012.05.017
微波促进立体选择性合成烯丙酸酯类高碳糖衍生物
Stereoselective Synthesis of Glycosyl Acrylate Derivatives by Microwave Assisted Wittig Reaction
摘要
Abstract
In order to develop an efficient, practical and stereoselective method for synthesizing glycosyl acrylate derivatives, the microwave assisted Wittig reaction of sugar ketone(l) and Lactones(4) with ylide 2 (Ph3P = CHCOOEt) was investigated in a sealed microwave reactor in various temperatures and solvents. The reaction was carried out effectively and stereoselectively in xylene at 180 ℃ with a yield up to 80% within 10 min.关键词
糖基烯丙酸酯类化合物/微波促进反应/Wittig反应/立体选择性Key words
Glycosyl acrylate derivative/ Microwave assisted reaction/ Wittig reaction/ Stereoselective synthesis分类
化学化工引用本文复制引用
王玮,李小六,李锐,张平竹,陈华..微波促进立体选择性合成烯丙酸酯类高碳糖衍生物[J].高等学校化学学报,2012,33(5):958-963,6.基金项目
国家自然科学基金(批准号:20672027,20972039)、国家“九七三”计划前期专项(批准号:2010CB534913)和北京大学天然药物及仿生药物国家重点实验室开放课题基金(批准号:20080205)资助. （批准号:20672027,20972039）
