波生坦治疗特发性肺动脉高压的临床疗效OA

Objective To explore the efficacy of bosentan in the treatment of idiopathic pulmonary arterial hypertension ( IPAH ).Methods 45 patients with IPAH were randomly assigned to study group ( 23 patients ) or control group ( 22 patients ).Both groups received conventional therapies and the study group was administered oral bosentan additionally.The efficacy was then analyzed in the two groups.Results 14 days after treatment,levels of PaO2 and 6MWD were higher whereas levels of PaCO2 and PAP were lower in the study group than in the control group [( 81 ± 3.7 )mmHg ( 1 mm Hg=0.133 kPa ) vs.( 57.0 ± 3.9 ) mm Hg and ( 331.0 ± 81.2 ) m vs.( 263.0 ± 58.9 ) m,and ( 43.0 ± 5.9 ) mmHg vs.( 66.0 ± 7.2 ) mm Hg and ( 63.0 ± 17.1 )mm Hg vs.( 78.0 ± 16.7 ) mm Hg; P ＜ 0.05 for all comparisons].Conclusions Oral bosentan is efficacious in the treatment of idiopathic pulmonary arterial hypertension,significantly reducing high pressure of pulmonary artery.