国际医药卫生导报2012，Vol.18Issue(10)：1406-1410,5.DOI:10.3760/cma.j.issn.1007-1245.2012.10.014
TopoⅡ及Ki67在基底细胞样乳腺癌中的表达及意义
Expression and clinical significance of ToPo Ⅱ and Ki67 Protein in Basal-like breast carcinoma
摘要
Abstract
Objective To study the expression and clinical significance of Ki67 protein and TOPPO Ⅱ protein in basal-like breast carcinoma (BLBC).Methods Invasive breast cancer specimens were selected in the Maternal and Child Service Center.22 cases were selected as BLBC group.And 83 cases of non-BLBC (NBLBC) were randomly selected as NBLBC group.All of samples used SP immunohistochemical method to detect the express of Topo-Ⅱ and Ki67 in different groups.Results The Ki67 protein' s posilive expression rate in four breast tissue was ( x2＝18.36,P=0.001 ),NBLBC group's Ki67 protein had statistically diffcrence with the BLBC group,showing that the BLBC group Ki67 protein expression rate level was the highest.Topo Ⅱ expression had close correlation with clinical pathologic stage.The result showed that in BLBC group,the higher the tumor histological grade,the higher the Topo Ⅱ protein expresaion( P＜ 0.05 ),and Topo Ⅱ positive rate of NBLBC group expressed highest in level Ⅱ.Further with Spearman rank correlation analysis (r=0.346,P=0.004) showed significant positive cortelation of the two proteins.Conclusion There was close relationship between Ki67 protein expression and histologic classification in BLBC and NBLBC groups.Topo Ⅱ expressed close correlation with histologic classification and TNM classification in BLBC and NBLBC groups.The express of Ki67 and Topo Ⅱ in BLBC is significantly higher than those in NBLBC.The express of Ki67 and Topo Ⅱ have positive correlation in BLBC.关键词
TopoⅡ/Ki67/基底细胞样乳腺癌Key words
Ki67/TOPO Ⅱ/Basal-like breast carcinoma引用本文复制引用
黄雅娟,于晓红,杜峰..TopoⅡ及Ki67在基底细胞样乳腺癌中的表达及意义[J].国际医药卫生导报,2012,18(10):1406-1410,5.
