NH2基修饰SiO2包覆的Fe3O4纳米管药物载体的制备及载药研究OACSTPCD
Preparation and drug loading study on amino modified silica encapsulated magnetite nanotubes drug carrier
目的 制备NH2基修饰SiO2包覆的Fe3O4纳米管药物载体并研究其载药性能.方法 使用水热法制备Fe2O3纳米管,然后用SiO2对其表面进行包覆,再使用H2还原制备SiO2包覆的Fe3O4纳米管,接着用3-氨丙基三乙氧基硅烷对其表面进行—NH2修饰,以水杨酸为模型药物研究所制备载体的载药性能.结果 成功制备出NH2基修饰SiO2包覆的Fe3O4纳米管药物载体,载药实验显示:以水为溶剂时,所制备的载体的包封率和载药率分别为54.7％和55.8％；…查看全部>>
Objective To prepare amino modified and silica encapsulated magnetite nanotubes drug carrier and study its drug loading properties. Methods Firstly,the hematite (Fe2O3) nanotubes were prepared by hydrothermal method,which were coated with SiO2 and reduced in H2 atmosphere. After that,the surface amino modification was carried out with 3-aminopropyltriethoxysilane. At last,the drug-loading properties of the prepared drug carrier were investigated with salicyl…查看全部>>
王丹;吕敏婷;谭钊杰
广东药学院药科学院,广东广州510006广东药学院药科学院,广东广州510006广东药学院药科学院,广东广州510006
化学工程
Fe3O4纳米管药物载体
iron oxide nanotube drug carrier
《广东药学院学报》 2012 (2)
128-131,4
广东药学院重点培养青年教师基金广东药学院人才引进科研启动基金项目(2007YKX15)
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