国际妇产科学杂志2012，Vol.39Issue(2)：196-198,213,4.
基质金属蛋白酶3及其抑制剂3在子痫前期患者胎盘中的表达
The Expression of Matrix Metalloproteinase-3 and Tissue Inhibitor of Metalloproteinases-3 in Placenta of Pregnant Women with Preeclampsia
程欣 1王永红1
作者信息
- 1. 030001太原,山西医科大学第二临床医学院妇产科
- 折叠
摘要
Abstract
To detect the expression of matrix metalloproteinases-3 (MMP-3 )and tissue inhibitor of metal-loproteinases-3 (TIMP-3 )in placenta of the patients with preeclampsia, and to investigate the role of MMP-3 and TIMP-3 in the pathogenesis of preeclampsia. Methods:The levels of MMP-3 and TIMP-3 in placental tissues were measured from 34 patients with preeclampsia (study group)and 32 normal pregnant women (control group)by immunohistochemistry. HE staining was used in order to count the number of the vessles. Results:MMP-3 and TIMP-3 were expressed in the decidual cell and the villous trophoblast in both group. Whether in decidual cell or in villi trophoblast cell, MMP-3 in preeclampsia group was significantly lower than that in the control group, but TIMP-3 was obviously higher in preeclampsia group. The count of vessels reduced in preeclampsia group. Conclusions:The differences of MMP-3 and TIMP-3 in placental tissues between preeclampsia group and control group suggest that those changes may associate with the pathogenesis of preeclampsia.关键词
先兆子痫/基质金属蛋白酶3/金属蛋白酶3组织抑制剂/胎盘Key words
Pre-eclampsia/ Matrix metalloproteinase 3/ Tissue inhibitor of metalloproteinase-3/ Placenta引用本文复制引用
程欣,王永红..基质金属蛋白酶3及其抑制剂3在子痫前期患者胎盘中的表达[J].国际妇产科学杂志,2012,39(2):196-198,213,4.
