国际口腔医学杂志2012，Vol.39Issue(4)：479-481,486,4.DOI:10.3969/j.issn.1673-5749.2012.04.017
肿瘤线粒体DNA损伤修复的研究进展
Research progress on mitochondrial DNA damage repair in tumors
摘要
Abstract
Mitochondria are organelles in mammalian cells, with the only genetic material outside the nucleus mitochondrial DNA(mtDNA). It supported and participated in many important cellular functions. MtDNA vulnera-bled to a variety of factors and cause damage because of special structures and advancement of genetics. When mtDNA damage happened, some mtDNA repair factors, such as: Mitochondrial transcription factor A, mtDNA poly-merase-γ, 8-oxoguanine DNA glycosylase enzymes take part in the damage repairing. The entire repair process were regulated by related factors.关键词
线粒体/肿瘤/线粒体转录因子A/线粒体DNA聚合酶/8-氧鸟嘌呤DNA糖基化酶Key words
mitochondria/ tumor/ mitochondrial transcription factor A/ mitochondrial DNA polymerase/ 8 -oxoguanine DNA glycosylase分类
生物科学引用本文复制引用
李鹤佳..肿瘤线粒体DNA损伤修复的研究进展[J].国际口腔医学杂志,2012,39(4):479-481,486,4.基金项目
黑龙江省自然科学基金资助项目(D201025) （D201025）
佳木斯大学校管青年基金资助项目(Sq2011-021) （Sq2011-021）
