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基质金属蛋白酶对牙本质粘接耐久性的影响OACSTPCD

Matrix metalloproteinases'influence on durability of dentin bonding

中文摘要英文摘要

基质金属蛋白酶(MMP)是一组分解细胞外基质的钙锌离子依赖型蛋白酶的总称.牙本质粘接剂酸性环境可以激活MMP酶原,进而分解暴露的胶原纤维,破坏粘接界面而导致粘接的失败.抑制MMP可有效增加粘接耐久性.本文就MMP在粘接过程中的激活和对粘接耐久性的影响以及MMP抑制剂的研究进展作一综述.

Matrix metalloproteinases (MMP) are a family of proteolytic enzymes with the main function of hy-drolyzing extracellular matrix, of which activity requires calcium and zinc ions. The acidic component of dentin adhesives can activate the pro-MMP to degrade the nude collagen fibrils and destroy the interface of resin-dentin bond which leads to the failure of binding. Inhibiting MMP will increase bond durability. The purpose of this article is to review t…查看全部>>

王恒

中山大学光华口腔医学院·附属口腔医院修复科,广州,510055

医药卫生

基质金属蛋白酶基质金属蛋白酶抑制剂乙醇湿粘接

matrix metalloproteinases matrix metalloproteinases inhibitor ethanol-wet bonding

《国际口腔医学杂志》 2012 (4)

498-500,3

10.3969/j.issn.1673-5749.2012.04.022

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