化工进展2012，Vol.31Issue(7)：1587-1591,1596,6.
丝素蛋白微球作为药物缓释载体的研究进展
Research progress of silk fibroin microsphere as sustained-release carrier of drug
摘要
Abstract
Silk fibroin（SF） is stable,non-toxic and cheap,and is an excellent carrier material due to its availability,biodegradability and biocompatibility.Based on its unique amino acids composition and stable structure of self-assembling β-sheets,several methods for preparation of SF microspheres/microparticles are introduced,such as enzymolysis,spray drying,emulsification solvent evaporation,phase separation,electrospraying,as well as the new technologies of suspension-enhanced dispersion by supercritical CO2（SpEDS）,and their sustained-release characteristics as drug carriers are also reviewed.In addition,it is recognized that challenges remain,including variation of silk between species and between individuals of the same species and inconsistencies in the degumming process.The future direction could be developing modified,composite or genetically engineered SF proteins,which would have potential applications in the biomedical field.关键词
药物载体/丝素蛋白/微球/制备Key words
drug carriers/silk fibroin protein/microspheres/preparation分类
医药卫生引用本文复制引用
党婷婷,陈爱政,王士斌..丝素蛋白微球作为药物缓释载体的研究进展[J].化工进展,2012,31(7):1587-1591,1596,6.基金项目
国家自然科学基金 （）
福建省自然科学基金（2010J05027,2011J01223）项目 （）
