整合素α9β1对角膜缝线术后新生淋巴管生成及血管内皮生长因子C表达的影响OA北大核心CSCDCSTPCD
Effect of integrin α9β1 on the lymphangiogenesis and expression of vascular endothelial growth factor C after corneal suture
目的 研究整合素α9β1对小鼠角膜缝线术后新生淋巴管及血管内皮生长因子C(VEGF-C)表达的影响并探讨其意义.方法 80只BALB/c小鼠,随机分为正常对照组、缝线对照组、α9β1组、α9β1抑制组,每组20只.正常对照组不作特殊处理；缝线对照组、α9β1组、α9β1抑制组小鼠制作双眼角膜缝线模型,术后分别予以左氧氟沙星、左氧氟沙星+α9β1、左氧氟沙星+d9β1单抗Y9A2点双眼,2次/d,共14d.术后第3、5、7、14、21天每组分别取2…查看全部>>
Objective To research the effect and clinical significance of integrin α9β1 on the corneal lymphangiogenesis and expression of vascular endothelial growth factor C (VEGF-C) after corneal suture. Methods 80 BALB/c mice were divided into 4 groups, namely normal control group, suture control group, α9β1 group, α9β1 suppression group, with 20 mice in each group. Normal control group received no treatment. Corneal suture was performed in the suture control group,…查看全部>>
吴静;赵敏
400016重庆 重庆医科大学附属第一医院眼科400016重庆 重庆医科大学附属第一医院眼科
医药卫生
整合素α9β1淋巴管生成角膜缝线血管内皮生长因子C
integrin alpha9betal lymphangiogenesis cornea sutures vascular endothelial growth factor C
《解放军医学杂志》 2012 (5)
壳聚糖纳米-siRNA干扰IL-2Rα表达对IL-2信号通路的影响及其在角膜移植免疫中的作用
421-425,5
国家自然科学基金(81170822)
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