中国乙型肝炎病毒流行株的适应性进化分析OACSTPCD
Adaptive evolution analysis of hepatitis B virus epidemic strains in China
目的:检测中国乙型肝炎病毒(HBV)B型和C型4个基因(区)(S、C、X和RT)的正选择位点,推断近年来中国HBV的变异趋势和原因.方法:从基因库下载中国所有B型和C型全长序列共864条,参照标准序列分别截取S、C、X和RT 4个基因(区),使用HyPhy方法筛选各基因序列集的正选择位点并进行统计和分析.结果:共检测到226个正选择位点(B型101个,C型125个),其中85个位点(B型37个,C型48个)分别位于75个(B型32个,C型43个)…a97105475
Objective; To detect evolution of hepatitis B virus (HBV) , its genotypes B and C circulating in China, and to evaluate the association of positive selection on four HBV gene regions [ S , C , X, and re-verse transcriptase (RT)] with immune escape. Methods; All available full-length genomic sequences (884 sequences ) of HBV genotypes B and C in China were downloaded from GenBank . Four gene segments of S, C, X, and RT were obtained from the genomic…Where did you go, Xiaohongshu will help you record it
黄艳;张朝;刘俊;徐庆刚
江苏大学生命科学研究院,江苏,镇江,212013江苏大学生命科学研究院,江苏,镇江,212013江苏大学生命科学研究院,江苏,镇江,212013江苏大学生命科学研究院,江苏,镇江,212013
医药卫生
乙型肝炎病毒B型C型正选择T细胞抗原表位耐药
hepatitis B virus genotype B genotype C positive selection T-cell epitopes drug resistance
《江苏大学学报（医学版）》 2012 (4)
312-319,323,9