摘要
Abstract
Objective; To study expression of β-catenin, MMP-7 and its significance in patients with gas-tric carcinoma. Methods: The expression of β-catenin in 75 tissue of gastric carcinoma was detected by im -munohistochemistry ABC method , and the expriession of MMP -7 in the positive tissue of β-eatenin in gastric carcinoma was detected by Western blot. Results; The protein of β-catenin was expressed in 35 of 75 cases in gastric carcinoma, the positive percentage is 46. 67%. However, the protein of β-catenin was expressed in 3 of 30 cases in normal gastric tissue , the positive percentage is 10. 00% . There was a significant differ-ence in statistical analysis (P <0.05). In addition, The protein of β-catenin was expressed in 44 of 62 ca-ses in patients with lympha node metastasis , the positive percentage was 70. 97%. And the positive per-centage of β-eatenin was 46. 15% in patients without lympha node metastasis (P <0. 05). The positive rate for β-catenin and MMP^7 were 73. 91% , 65. 22% respectively in poor-differentiated gastric carcinoma , while they were 47. 36% , 42. 10% respectively in moderately differentiated gastric carcinoma and 50.00% , 40.00% respectively in well differentiated gastric carcinoma. There was a significant difference in statistical analysis (P<0. 05). The positive immunostaining rate for MMP-7 in the area of a positive im-munostaining reaction of β-eatenin was high in gastric carcinoma (60. 00%). The expression of MMP-7 was significantly correlated with β-eatenin expression (r =0. 617 ,P <0. 01 ). Conclusion; The expres-sion of β-eatenin, MMP-7 in gastric carcinoma are related to the infiltration and metastasis of gastric carci -noma.关键词
胃癌/β-连环蛋白/基质金属蛋白酶-7/蛋白质印迹Key words
gastric carcinoma/ β-eatenin/ matrix metalloproteinase-7 / Western blot分类
医药卫生
