胸腺五肽微乳的处方筛选及质量评价OA北大核心CSCDCSTPCD
Formulation of thymopentin microemulsion and its quality evaluation
目的 对胸腺五肽反相微乳处方进行筛选并予以评价.方法 采用Km值滴定法(Km=m乳化剂∶m助乳化剂)绘制反相微乳各体系的伪三元相图,考察亲水疏水平衡值(hydrophile-lipophile balance number,HLB)、Km值、表面活性剂、助表面活性剂、油相等对反相微乳形成区域及最大载水量的影响,最终确定处方.结果 通过绘制伪三元相图,确定微乳的最终处方为油相∶大豆磷脂∶助表面活性剂∶水相=4∶1.67∶3.33∶1,该体系具有较大…查看全部>>
Objective To formulate and evaluate the thymopentin microemulsion. Methods Pseudo-ternary phase diagram was constructed by Km titration. The influence of HLB value, Km value, surfactant, co-surfactant and oil on formulation regions and water-loading was investigated to get the optimal prescription. Results According to pseudo-ternary phase diagram, the optimal formula is oil, surfactant, co-surfactant, water = 4: 1. 67: 3. 33: 1. This system possesses higher…查看全部>>
贾煜娇;徐风华
河北北方学院,河北张家口,075000解放军总医院药品保障中心,北京,100853
医药卫生
胸腺五肽反相微乳Km值滴定法伪三元相图
Thymopentin ireverse microemulisionKm titration method peaudo-temnary phase diagram
《军事医学》 2012 (7)
531-534,4
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