军医进修学院学报2012，Vol.33Issue(8)：876-878,3.DOI:10.3969/j.issn.1005-1139.2012.08.031
中链脂肪酸对糖尿病小鼠脂代谢的影响及相关机制研究
Effect of medium chain fatty acid on lipid metabolism of mice with diabetes mellitus and its mechanism
宫雪 1张永 1刘英华 1张新胜 1于晓明 1徐庆 1王觐 1杨雪艳 1薛长勇1
作者信息
- 1. 解放军总医院,营养科,北京,100853
- 折叠
摘要
Abstract
Objective To study the effect of medium chain fatty acid on lipid metabolism of mice with diabetes mellitus(DM) and its mechanism. Methods Thirty-six male kkay DM mice were randomly divided into 3 groups(12 in each group). After they were fed with high fat diet containing octoic acid(1.5%, C8), capric acid(1.5%, C10)and oleinic acid(1.5%, OA), respectively, for 12 weeks, their body weight and body fat, and triglyeride(TG), cholesterol(TC), free fatty acid(FFA), lipoprotein lipase(LPL), fatty acid synthetase(FAS)and acetyl-CoA-carboxylase(ACC) levels were measured. Results Twelve weeks after the mice were fed with octoic acid, capric acid and oleinic acid, their body weight and body fat around mesenterium, epididymis and kidney, and LPL, FAS, ACC, TG, TC, LDL-C and FFA levels were significantly lower in octoic acid group and capric acid group than in oleinic acid group(42.84 ± 1.57)g and (42.19 ± 1.64)g vs (45.60 ± 0.77)g, (P<0.05). Conclusion Octoic acid and capric acid can significantly reduce the body weight and body fat of DM mice by decreasing the activity of synthetase and increasing the activity of oxidase in medium chain fatty acid.关键词
中链脂肪酸/糖尿病小鼠/甘油三酯/脂肪酸合成酶Key words
medium chain fatty acid/ diabetic mice/ triglyeride/ fatty acid synthetase分类
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宫雪,张永,刘英华,张新胜,于晓明,徐庆,王觐,杨雪艳,薛长勇..中链脂肪酸对糖尿病小鼠脂代谢的影响及相关机制研究[J].军医进修学院学报,2012,33(8):876-878,3.
