临床肝胆病杂志2012，Vol.28Issue(4)：285-288,4.
肝脏瞬时弹性值评估慢性乙型肝炎肝纤维化程度及肝脏储备功能的临床研究
Evaluation of degree of liver fibrosis and liver functional reserve in patients with chronic hepatitis B using FibroScan score
摘要
Abstract
Objective To investigate the correlation between FibroScan (FS) score and liver fibrotic tissue area in patients with chronic hepatitis B and to assess the value of FS in detecting liver fibrosis, as well as analyze the relationship between change of FS in patients with liver cirrhosis due to HBV infection and liver CTP classification. Methods 30 healthy people (control group), 113 patients including 62 patients with chronic HBV hepatitis ( HBV group) and 51 patients with cirrhosis due to HBV infection ( Cirrhosis group) were enrolled in this study. All patients were subjected to Abdominal Ultrasonography and FibroScan. Meanwhile, all the laboratory tests of patients were collect to evaluate the Child - Turcotte - Puge( CTP) score. Then the patients were divided into three groups according to CTP score (Child A, Child B, Child C group). In addition, liver specimens obtained via Percutaneous transhepatic biopsy was stained by Masson staining for detecting the fibrotic tissue. The fibrotic area was analyzed by computer - assisted digital image system. Finally, the correlation between the FibroScan (FS) score and fibrotic area in liver specimens and the relationship between change of FS score and CTP grade were assessed. Results The comparison in FS score between the HBV group and control group, and between the cirrhosis group and CHB group both were statistically significant (P <0. 05). In cirrhosis group, the FS score increased corresponding to the increase of the CTP grade. The comparisons among the Child A,B,C groups all were statistically significant(P <0. 05). The FS score was correlated with the fibrotic area in liver tissue and the correlation coefficient was 0.804 (P < 0.01). Conclusion FS score showed excellent correlation with the liver fibrotic area, and FS score in patients with cirrhosis increased corresponding to the increase of the CTP grade, which might be used to assess the degree of liver fibrosis and evaluate the liver reserve function to some extent.关键词
FibroScan/肝炎,乙型,慢性/肝硬化Key words
FibroScan/ hepatitis B, chronic/ liver cirrhosis分类
医药卫生引用本文复制引用
宣吉晴,李明星,苏松,陈晓梅,李烨,郭庆喜..肝脏瞬时弹性值评估慢性乙型肝炎肝纤维化程度及肝脏储备功能的临床研究[J].临床肝胆病杂志,2012,28(4):285-288,4.基金项目
四川省泸州市科技局重点资助项目(2010-S-14(5/16)) （2010-S-14(5/16）
