临床口腔医学杂志2012，Vol.28Issue(6)：345-349,5.DOI:10.3969/j.issn.1003-1634.2012.06.009
OLP和OSCC中p16和miR-137基因甲基化的初步研究
The p16 and miR-137 methylation in oral lichen planus and oral squamous cell carcinoma
摘要
Abstract
Objective:To investigate pl6 gene and miR-137 gene methylation in lichen planus mucnsa and oral squamous cell carcinoma. Method: 10 patients of oral lichen planus and 10 patients with OSCC were studied on pl6 and miR-137 methylation. Result:Rates of pl6 and miR-137 methylation were 20 % and 50% for patients of oral lichen planus, 50 % and 60 % for patients of OSCC. There were no statistically significant differences of pl6 gene or miR-137 gene methylation rates between two groups. Rates of pl6 gene and miR-137 gene methylation were associated with patients' age> gender and stage of the tumor respectively. Conclusion: There were aberrant methylation of pl6 gene and miR-137 gene in oral lichen planus tissues. Male.aged patients showed higher methylation rates of p16 gene and miR-137 gene. More samples are needed for further comparasion and indication analysis.关键词
口腔扁平苔藓/癌变/p16/miR-137/甲基化Key words
oral lichen planus/canceration/p16,miR-137:methylation分类
医药卫生引用本文复制引用
党军,边永钎,孙建勇,王欣,陈芳,董广英,刘青,王新文,王勤涛..OLP和OSCC中p16和miR-137基因甲基化的初步研究[J].临床口腔医学杂志,2012,28(6):345-349,5.基金项目
军队十一五医药卫生科研基金(08G105) （08G105）
