临床眼科杂志2012，Vol.20Issue(4)：364-367,4.DOI:10.3969/j.issn.1006-8422.2012.04.027
屈光参差性弱视视放射及胼胝体的扩散张量成像研究
Study on the optic radiation and corpus callosum in children with anisometropic Amblyopia by diffusion tensor imaging
摘要
Abstract
Objective To evaluate the development of optic radiations ( ORs) and corpus callosum in children with anisometropic amblyopia by using diffusion tensor imaging (DTI) ,and to explore the underlying mechanism of patho-genesis of amblyopia. Methods Fourteen children with anisometropic amblyopia ( all left eyes) and 30 normally sighted children underwent DTI scanning. The fractional anisotropy (FA) values and the apparent diffusion coefficient ( ADC) values of ORs and corpus callosum were measured . Comparisons of FA values and ADC values were made both within the groups (Left to Right comparison) and between the two groups. Results In both groups , the FA values of left ORs were higher than those of right ORs and the ADC values of left ORs were lower than those of right ORs ( P < 0. 05 ). The FA values of ORs in children with amblyopia were lower than those of ORs in children with normal sights ( P <0. 05) , while the ADC values of ORs were higher ( P <0. 05 ). And the ADC values of splenium corporis callosi in children with ambly -opia were higher than those of splenium corporis callosi in children with normal sights ( P < 0. 05). Conclusion The difference between the anisometropic amblyopia and the normal controls reflect the underdevelopment of ORs and splenium corporis callosi in children with anisometropic amblyopia .关键词
扩散张量成像/弱视/视放射/胼胝体Key words
Diffusion tensor imaging / Amblyopia, Optic radiations , Corpus callosum引用本文复制引用
吴进,曾洪武,方佃刚,干芸根,张莉,李雯霖,钟晖..屈光参差性弱视视放射及胼胝体的扩散张量成像研究[J].临床眼科杂志,2012,20(4):364-367,4.基金项目
深圳市科技计划项目(编号:201103146) （编号:201103146）
