临床与实验病理学杂志2012，Vol.28Issue(7)：726-731,6.
乳腺包裹性乳头状癌17例临床病理观察
A clinicopathologic study of breast encapsulated papillary carcinoma
摘要
Abstract
Purpose To elucidate the clinicopathologic features of encapsulated papillary carcinoma ( EPC ) of the breast. Methods The clinicopathologic features and immunohistochemical results of 17 cases of breast EPC were reviewed. The antibody used for iininu-nohistochemical staining included p63, SMA, CK5/6, ER, PR, HER-2 and Ki-67. Follow-up data for the patients was got. Results Of the 17 EPC patients, 16 were females, with a mean age of 62 years. Palpable mass and nipple discharge were the most common symptoms. EPCs ranged in size from 1. 5 to 5. 5 cm( mean 2. 9 cm ), and 10 cases were cystic. Microscopic examination showed single or multiple lesions surrounded by a rim of fibrous connective tissue. The majority of EPCs demonstrated the classic features of a papillary architecture lined by tall columnar epithelial cells. The minority presented a cribriform or solid glandular pattern. One patient had metastasis carcinoma in 1 axillary lymph node. Myoepithelial cell staining was negative for p63, SMA and CK5/6 within the tumor and at the periphery of the tumor. The tumor cells were positive for ER and PR. Only 1 case showed 2( + ) staining for HER-2, and the rest were negative. The average positive percentage for Ki-67 was 12% . Follow-up was available in 10 cases, and no patient had recurrence , distant metastasis or death. Conclusions EPC lacking a peripheral layer of myoepithelial cells can be regarded as a special type of invasive carcinoma associated with better prognosis, and can be treated like the therapy of DCIS.关键词
乳腺肿瘤/包裹性乳头状癌/免疫组织化学Key words
breast neoplasms/ encapsulated papillary carcinoma/ immunohistochemistry分类
医药卫生引用本文复制引用
刘裔莎,魏兵,步宏,张璋,王剑威,陈卉娇,张红英..乳腺包裹性乳头状癌17例临床病理观察[J].临床与实验病理学杂志,2012,28(7):726-731,6.基金项目
国家自然科学基金资助(81172536) （81172536）
