临床与实验病理学杂志2012，Vol.28Issue(7)：768-771,4.
Elf-1在非小细胞肺癌中的表达与肿瘤细胞凋亡及患者预后的关系
Expression of Elf-1 in non-small cell lung cancer and its correlationship with prognosis of patients and tumor cell apoptosis
杨东霞 1李乃娥2
作者信息
- 1. 滨州医学院基础学院病理学教研室,烟台,264003
- 2. 滨州医学院临床学院诊断学教研室,烟台,264003
- 折叠
摘要
Abstract
Purpose To investigate the expression of Elf-1 in NSCLC and to explore the relationship between expression of Elf-1 with survivin which is the most effective inhibitor of apoptosis protein( IAP ) in non-small cell lung cancer ( NSCLC ). Methods Power Vi-sion-9000 immunohistochemistry was used to evaluate the expression of Elf-1 in tissue microarray containing 60 specimens of NSCLC and 9 specimens of normal tissue. The apoptotic cells were tested by terminal deoxynucleotidy transferase( TdT ) mediated Dutp-biotin nick end labelling ( TUNEL ). Results Elf-1 was detected in 1 of 9 normal tissues with weak positive, the positive rate of Elf-1 was 70% in NSCLC. The expression level of Elf was significantly associated with tumor differentiation, lymph node metastasis, clinical stage, and postoperative survival time ( all P < 0. 05 ). Overexpression of Elf-1 was associated with poor prognosis: the survival rate was significantly lower in positive patients than in negative patients ( P < 0. 01 ). Elf-1 expression in NSCLC was negatively associated with AI ( r = - 0. 708, P < 0. 01 ). Conclusion The results show that Elf-1 expression in NSCLC correlates with decreased apoptosis of tumor cells. Detecting of Elf expression can help to predict the malignant behavior of NSCLC.关键词
肺肿瘤/非小细胞肺癌/Elf-1/凋亡/预后Key words
lung neoplasms/ non-small cell lung cancer/ Elf-1/ prognosis/ apoptosis分类
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杨东霞,李乃娥..Elf-1在非小细胞肺癌中的表达与肿瘤细胞凋亡及患者预后的关系[J].临床与实验病理学杂志,2012,28(7):768-771,4.
