摘要
Abstract
Purpose To investigate the expression of 53BP1 in squamous cell carcinoma and precancerous lesions of the cervix, and to expolore the role of 53BP1 in the carcinogenesis of cervical cancer. Methods Immunohistochemical En Vision was used to detect the expression of 53BP1 in 10 cases of normal cervix tissue, 20 cases of cervical intraepithelial neoplasm l( CIN1 ), 20 cases of CIN2, 20 cases of CIN3, and 20 cases of squamous cell carcinoma. Results Focal positive expression of 53BP1 was seen in 2 cases of normal cervical tissue and the positive rate of 53BP1 in the normal cervix was 20%. The positive rates of 53BP1 in CIN1, CIN2, CIN3 and cancer were all 100% . There was significant differences between normal tissue and CIN1, CIN2, CIN3 and cancer( P < 0. 01 ). The diffuse positive rates of 53BP1 in the normal cervix and CIN1 were 0, but the diffuse positive rates of 53BP1 in the CIN2, CIN3 and cancer were 55% , 70% and 100% . The diffuse positive rates of 53BP1 in the CIN2, CIN3 and cancer were higher than that in normal tissue and CIN1 ( P <0. 01 ). There was no difference of'53BPl expression between CIN2 and CIN3 ( P = 0. 327 ). The diffuse positive expression of 53BP1 in the squamous cell carcinoma was higher than that in CIN3 and CIN2 ( P =0. 020, P =0. 001 ). Conclusions Expression of 53BP1 may be a marker for genomic instability and genomic instability may be a early event in the carcinogenesis of cervical cancer.关键词
子宫颈肿瘤/53BP1/基因组不稳定性/肿瘤发生Key words
cervical neoplasms/ 53BP1/ genomic instability/ carcinogenesis分类
医药卫生
