中国临床保健杂志2012，Vol.15Issue(3)：277-279,后插3,4.DOI:10.3969/J.issn.1672-6790.2012.03.020
依达拉奉改善一氧化碳中毒迟发性脑病大鼠学习记忆能力和海马CA1区神经元的研究
Edaravone improves memory and hippocampal CA1 area neurons in rats with delayed neuropsychological sequelae after acute carbon monoxide poisoning
摘要
Abstract
Objective To observe and evaluate the effect of free radical scavenger edaravone in improving memory and hippocampal CM area neurons in rats with delayed neuropsychological sequelae (DNS) after acute carbon monoxide poisoning. Methods 40 male SD rats were randomly divided into 4 groups with 10 rats each group: normal control group, DNS group, saline group and edaravone group. Spatial learning and memory was detected by Morris water maze in each group. Hippocampal CA1 area neurons were counted by microscope. Results Escape latency and cross platform frequency in edaravone group were better than that in saline group and DNS group ( P < 0.05). Hippocampal CA1 area neurons in edaravone group was significantly much more than that in saline group and DNS group (P<0.05). Conclusion Edaravone may improve impaired spatial memory and hippocampal CA1 area neurons in DNS rats.关键词
一氧化碳中毒/谵妄,痴呆,遗忘,认知障碍/依达拉奉/大鼠,sprague-dawleyKey words
Carbon monoxide poisoning/ Delirium, dementia, amnestic, cognitive disorders/ Edaravone/ Rats, sprague-dawley分类
医药卫生引用本文复制引用
汪青松,刘学春,管叶明,刘红娟,王静,黄海丽,王强..依达拉奉改善一氧化碳中毒迟发性脑病大鼠学习记忆能力和海马CA1区神经元的研究[J].中国临床保健杂志,2012,15(3):277-279,后插3,4.基金项目
全军十一五医药卫生科研基金课题(06H009) （06H009）
南京军区医药卫生科研基金课题(06MA51) （06MA51）
