中国临床保健杂志2012，Vol.15Issue(3)：280-282,后插4,4.DOI:10.3969/J.issn.1672-6790.2012.03.021
黄连素对实验性2型糖尿病大鼠黄嘌呤氧化酶的影响
The effect of berberine on xanthine oxidase activity in the serum and the renal tissue of experimental type 2 diabetic rats
赵洪涛 1孙凯 2郑慧哲1
作者信息
- 1. 牡丹江医学院病理生理学教研室,牡丹江157011
- 2. 黑龙江省高校肿瘤疾病防治重点实验室
- 折叠
摘要
Abstract
Objective To investigate the effects of berberine on the activity of XOD in the serum and renal tissue of type 2 diabetes rats. Methods The model of type 2 diabetic rats was established by the injection of a small - dose streptozotocin combined with high glucose and fat feeding. The rats model was treated with berberine (0.1 g · kg -1 · d-1). After 8 weeks, We detected XOD activity in the serum and kidney. Results Compared to diabetic rats, the activity of the XOD in the serum and renal tissue of rats treated with berberine decreased obviously, P < 0.01:Through pathological observation,the number of endothelial cells in berberine rats increased slightly,better than that in the rats with diabetes. Conclusions Berberine could reduce xanthine oxidase activity in vivo and delay the occurrence and development of diabetic kidney disease.关键词
糖尿病,2型/小檗碱/黄嘌呤氧化酶/大鼠,WistarKey words
Diabetes mellitus, type 2/ Berberine/ Xanthine oxidase/ Rats, Wistar分类
医药卫生引用本文复制引用
赵洪涛,孙凯,郑慧哲..黄连素对实验性2型糖尿病大鼠黄嘌呤氧化酶的影响[J].中国临床保健杂志,2012,15(3):280-282,后插4,4.
