环境与职业医学2012，Vol.29Issue(4)：203-205,209,4.
慢性铝暴露对小鼠学习记忆及tau蛋白磷酸化的影响
Effects of Chronic Aluminum Exposure on Learning and Memory and the Phosphorylation of Tau Protein in Mice
摘要
Abstract
To explore the effect of chronic aluminum exposure on learning and memory and the phosphorylation levels of tau protein in mice. [ Methods ] Three groups of mice were fed with AlCl3 at 120.0, 12.0 and 1.2 mg/(kg·d) respectively for 1 year, and one control group with normal diet. Spatial learning and memory ability were tested with Morris water maze (MWM). Brain aluminum content was determined by inductively coupled plasma mass spectrometry (ICP-MS). The expression of total tau and phosphorylated tau in Thrl81, Thr231, Ser262 and Ser396 sites in brain tissues of mice were detected by Western blot. [ Results ] Compared with the control group, the MWM latent period of high and middle dose groups was significantly prolonged (P<0.05); the number of traversing platform in high and middle dose groups were significantly decreased (P<0.05); and brain aluminum levels of all 3 exposure groups were significantly higher (P < 0.05). Western blot test demonstrated that the total tau and the phosphorylation levels in Thrl81, Thr231, Ser262 and Ser396 sites of all 3 exposure groups were significantly higher than those of the control group (P<0.05). [ Conclusion ] Aluminum exposure can lead to cognitive dysfunction in mice and the overphosphorylation of tau protein, which may be one of the mechanisms of cognitive dysfunction induced by aluminum.关键词
铝/学习记忆/tau蛋白/磷酸化Key words
aluminum/ learning and memory/ tau protein/ phosphorylation分类
天文与地球科学引用本文复制引用
贾志建,路小婷,潘宝龙,王昊,刘莹,牛侨..慢性铝暴露对小鼠学习记忆及tau蛋白磷酸化的影响[J].环境与职业医学,2012,29(4):203-205,209,4.基金项目
国家自然科学基金对外交流与合作项目(编号:30910103003) （编号:30910103003）
教育部博士点基金(编号:200801140002) （编号:200801140002）
