国际眼科杂志2012，Vol.12Issue(8)：1433-1437,5.DOI:10.3969/j.issn.1672-5123.2012.08.03
Skp2,p27,PTEN在眼附属器B细胞非霍杰金淋巴瘤中的表达
Expression of Skp2,p27,PTEN proteins in B-cell non-Hodgkin lymphoma of ocular adnexa
张静静 1赵桂秋 1周扬 1杨先1
作者信息
- 1. 266003,中国山东省青岛市,青岛大学附属医院眼科
- 折叠
摘要
Abstract
AIM: To investigate the expression of Skp2，p27 and PTEN proteins in B-cell non-Hodgkin lymphoma(NHL) of ocular adnexa.NHL (n=30) and lymphadenosis (n=10) of ocular adnexa in Qingdao Affiliated Hospital from 1995 to 2011. Features (age, gender, pathogenetic locations, pathological type) can be used as factors to classify 30 cases of B-cell NHL. Lymphadenosis sections were selected to the control group. The expression of Skp2,p27 and PTEN proteins were detected by immunohistochemistry and the positive expression rate between lymphomas and lymphadenosis was compared. Spearman rank correlation was used to estimate the relationships among Skp2, p27 and PTEN in ocular lymphoma. pathogenetic locations but related to pathologic type of tumors. In B-cell NHL specimens, the expression of p27kip1 and PTEN was lower than that in lymphadenosis (P<0.05), while the expression of Skp2 was higher.Skp2 labeling frequency was increased dramatically in plasmacytoma(PL) and diffuse large B-cell lymphoma(DLBCL) compared with mucosa-associated lymphoid tissue(MALT)(P<0.01). While p27kip1 and PTEN labeling frequency in PL and DLBCL was significantly lower than that of MALT(P<0.05,P<0.01). There was a negative correlation between p27kip1 and Skp2 in MALT(r=-0.134, x2=12.58,P＜0.05)while there was a positive correlation between p27kip1 and PTEN(r=0.828, x2=20.66,P＜0.05).The relationship between Skp2 and PTEN was also negative(r=-0.883, x2=20.52,P＜0.05).play an important role in the tumorigenesis and different pathologic type in ocular adnexal tumors. The expression of three proteins correlates with each other in MALT. Combined examination of Skp2,p27 and PTEN is a valuable marker to predict the presence of the B-cell NHL of ocular adnexa and differentiate the pathologic type of tumors.关键词
眼附属器/非霍杰金淋巴瘤/Skp2/p27kip/PTEN/免疫组织化学检验Key words
ocular adnexa/non—Hodgkin lymphoma/Skp2/p27kip1/PTEN/immunohistochemistry引用本文复制引用
张静静,赵桂秋,周扬,杨先..Skp2,p27,PTEN在眼附属器B细胞非霍杰金淋巴瘤中的表达[J].国际眼科杂志,2012,12(8):1433-1437,5.
