南京医科大学学报（自然科学版）2012，Vol.32Issue(4)：454-457,4.
胃癌中水通道蛋白3的表达与淋巴结转移的关系
Expression of aquaporin-3 in gastric adenocarcinoma and the relationship with lymph node metastasis
摘要
Abstract
Objective;To investigate the expression difference of aquaporin-3 (AQP3) in each stage of gastric adenocarcinoma (GAC),and the relationship with lymph node metastasis. Methods:Collecting 80 cases of gastric adenocarcinoma tissue and corresponding nontumor tissue,the AQP3 expression of mRNA and protein in each sample were detected by quantitative real time polymerase chain reaction (qPCR) and Western blot. Then,the relationship between AQP3 expression and clinicopathologic characteristics of the patients was analyzed. Results:The different expressions of AQP3 in each stage of CAC (T1,T2,T3,T4), according to UICC(2010),had effects on lymph node metastasis;The expression of AQP3 in tumor tissue with lymph node metastasis was higher than that without lymph node metastasis. Conclusion;The overexpression of AQP3 in GAC might stimulate the occurrence of lymph node metastasis. The overexpression of AQP3 can be taken as a biomarker of GAC prognosis and metastasis. AQP3 might be a therapy target of gastric adenocarcinoma.关键词
水通道蛋白3/胃腺癌/淋巴结转移Key words
aquaporin-3(AQP3)/gastric adenocarcinoma (GAC) /lymph node metastasis分类
医药卫生引用本文复制引用
徐勇,张文杰,杨力,徐泽宽,徐皓..胃癌中水通道蛋白3的表达与淋巴结转移的关系[J].南京医科大学学报（自然科学版）,2012,32(4):454-457,4.基金项目
国家自然科学基金资助(30901421) （30901421）
江苏省卫生厅开放课题(XK03200903) （XK03200903）
