南京医科大学学报（自然科学版）2012，Vol.32Issue(4)：536-539,4.
冠心病患者血清S100A12水平升高的临床意义
Serum level of S100A12 and its correlation in coronary heart disease
杨玲 1贺骞 1王强 1陈巍 1孙建辉1
作者信息
- 1. 苏州大学附属第三医院心内科,江苏常州213003
- 折叠
摘要
Abstract
Objective: To investigate the serum level of S100A12 in coronary heart disease (CHD) patients and approach the effects of S100A12 in diagnosis of CHD. Methods: One hundred and twenty-eight patients who underwent CHD and sixty-one patients with normal coronary artery CTA or coronary angiography were selected in the study. Serum level of S100A12 was measured by ELJSA assay. The relationship between serum level of S100A12 and the pathogenetic conditions of CHD were analyzed by logistic regression. Results; The serum level of S100A12 [(43.57 ± 10.30) ng/ml] in CHD group was significantly higher than those in serum of non-CHD group [(25.63 ± 7.42) ng/ml] (P < 0.001),and positively related with the coronary stenosis Censini severity score (r = 0.391,P < 0.001). Further logistic regression analysis indicated that after ruling out the other risk factors,such as age,male,BMI overweight,high blood pressure,diabetes,and blood lipid abnormalities,S100A12 also had significant correlation with CHD (OR = 2.67, P < 0.001). Conclusion; The serum level of S100A12 may be a potential biological indicator to predict the risk for CHD.关键词
冠心病/S100A12/危险因素Key words
coronary heart disease/S100A 12/risk factors分类
医药卫生引用本文复制引用
杨玲,贺骞,王强,陈巍,孙建辉..冠心病患者血清S100A12水平升高的临床意义[J].南京医科大学学报（自然科学版）,2012,32(4):536-539,4.
