日用化学工业2012，Vol.42Issue(3)：234-236,3.
高效液相色谱法测定功效化妆品中盐酸特比萘芬
Determination of tertinafine hydrochloride content in functional cosmetics by high performance liquid chromatography
李彦博 1王超 1赵晓冬 1陆军 1陈晓辉2
作者信息
- 1. 辽宁省食品药品检验所 化妆品室,辽宁 沈阳 110023
- 2. 沈阳药科大学 药学院,辽宁 沈阳 110016
- 折叠
摘要
Abstract
A reversed - phase high performance liquid chromalography for the determination of tertinafine hydrochloride in functional cosmetics was established. The sample was analyzed on a Waters C18 column (4. 6 mm × 150 mm,5 μm) with detecting wavelength of 280 run at 25 ℃. The mobile phase is composed of tetrahydrofuran (THF) , telramethylammonium hydroxide solution and acetonitrile (CH3CN) with ratio of V(THF): V ( tetramethylammonium hydroxide solution) : V ( CH3CN ) = 15 : 15 : 70, at a flow rate 1.0 mL · min-1 . Results showed that as the mass concentration of tertinafine hydrochloride is in the range of 5.27-84.32 mg · L-1,the relationship between the mass concentration and the corresponding peak area shows good linearity ( r = 1. 000 0) . The recoveries of tertinafine hydrochloride achieved 91. 6% ～ 102. 6% .关键词
化妆品/盐酸特比萘芬/高效液相色谱法Key words
cosmetics/tertinafine hydrochloride/high performance liquid chromatography分类
化学化工引用本文复制引用
李彦博,王超,赵晓冬,陆军,陈晓辉..高效液相色谱法测定功效化妆品中盐酸特比萘芬[J].日用化学工业,2012,42(3):234-236,3.
