四川医学2012，Vol.33Issue(5)：748-751,4.
钙激活钾通道电流在膀胱逼尿肌不稳定中的表达变化研究
The Change of Large Calcium Activated Potassium Channels (BKCa) in the Rats with Detrusor Instability
杨四文 1殷波1
作者信息
- 1. 攀枝花市第二人民医院泌尿外科,四川攀枝花617068
- 折叠
摘要
Abstract
To observe the change of large calcium activated potassium channels (BKca) in the rate with detrusor instability (DI) and discuss the role of BKca in DI. Methods Model of DI of female rate was prepared by ligating the proximal urethra in the perimeum. The single bladder smooth muscle cell was acquired by digesting the bladder smooth muscle with enzyme. Whole-cell BKca currents were recording with perforated whole-eel congfiguration. Results There were plenty of BKca currents detected in bladder smooth muscle cells and these electrophysiological properties ere consistent with BKca in other tissues, including outside rectification and being blocked by IbTX, a special blocker of BKca The amplitude of BKca in DI group was decreased in several membrane voltages. The current density at Vm= +60 mV was decreased to (20±4.63) pA/pF (n = 18) , compared with the control group (32.42 ±7.97) pA/pF (n=21) , P<0. 01. Conclusion BKca currents were decreased in rat DI, which may be involved in the DI and BKca may beome one therapeutical target of DI.关键词
逼尿肌不稳定/钙激活钾通道/膀胱出口梗阻Key words
detrusor instability/ BKca/ bladder outlet obstruction分类
医药卫生引用本文复制引用
杨四文,殷波..钙激活钾通道电流在膀胱逼尿肌不稳定中的表达变化研究[J].四川医学,2012,33(5):748-751,4.
