四川医学2012，Vol.33Issue(7)：1169-1171,3.
低剂量纳洛酮对曲马多镇痛效应的影响
The effect of low-dose naloxone on analgesia of tramadol
陈春 1龚园 1杨鹏 1冯雪刚 1汤和青 1侯俊 1方为1
作者信息
- 1. 三峡大学第一临床学院麻醉科,湖北,宜昌,443003
- 折叠
摘要
Abstract
To explore the effect of low-dose naloxone on analgesia of tramadol. Methods Eighty patients undergoing general anesthesia for elective total abdominal hysterectomy were randomly divided into four groups. All patients received 2mg/kg tramadol 30 minutes before the end of surgery followed by a continuous infusion with 20mg/kg tramadol with no naloxone (group I n = 20) , 2.4μg/kg naloxone (group II n =20) , 4. 8μg/kg naloxone (group Ⅲ n=20) , 9.6μg/kg (group IV n =20) ,diluted to 100ml. Pain assessments were recorded one hour after starting the PCIA and then at 6.12 and 24 hours by u-sing visual analogue scale ( VAS) . Nausea Vomiting score, sedation score and side effect were also recorded. Results Seventy-five patients were included in this study. The intravenous tramadol administration provided the satisfied analgesia. There was no significant difference in VAb scores among naloxone groups and control group, compared with control group ,sedation was less in group Ⅱ Ⅲ and IV at 6,12 and 24 hours, P < 0. 05. The incidence of nausea vomiting in the naloxone group was lower than control group, P < 0. 05. Conclusion A small-dose naloxone infusion could reduce tramadol induced side effects without reversing its analgesia effects.关键词
纳洛酮/曲马多/低剂量/镇痛Key words
naloxone/ tramodal/ low-dose/ analgesia分类
医药卫生引用本文复制引用
陈春,龚园,杨鹏,冯雪刚,汤和青,侯俊,方为..低剂量纳洛酮对曲马多镇痛效应的影响[J].四川医学,2012,33(7):1169-1171,3.
