肿瘤预防与治疗2012，Vol.25Issue(4)：215-219,5.DOI:10.3969/j.issn.1674-0904.2012.04.003
64层灌注CT血容量图评价兔VX2脑瘤模型三维适形放疗解剖学靶区的实验研究
An Experimental Study on Anatomical Target Volume of Rabbit VX2 Brain Tumor Model for Three-dimensional Conformal Radiotherapy Planning: Evaluation with Blood Volume from 64-slice Spiral Computed Tomography Perfusion Imaging
摘要
Abstract
Objective: To investigate the role of blood volume from 64-slice spiral computed tomography perfusion imaging in the evaluation of tumor gross tumor volume( GTV ) and clinical target volume ( CTV ) in rabbit VX2 brain tumor model for three dimensional conformal radiotherapy planning. Methods: Perfusion CT was performed in 20 rabbit VX2 brain tumor model established successfully. The maximum long and minimum short diameter of the blood volume maps from the 20 rabbit VX2 brain tumor model were measured and compared to the GTV and CTV of the same section in the pathological specimens. Results: Among 20 rabbit VX2 brain tumor models, the mean differences of maximum long and minimum short diameter between tumor GTV with pathologic confirmation (7.98 mm±2. 11mm and 4. 40 mm ± 1. 19 mm )and BV maps( 11.98 mm ± 3. 29 mm and 7. 03 mm ± 1. 82mm ) ( P =0.000) were significant. The mean value of maximum long and minimum short diameter of tumor CTV with pathologic confirmation were 12. 87 mm ±3. 74mm and 7. 64 mm ±2. 05 mm respectively. There were no differences between tumor pathologic CTV and BV maps( P = 0. 052 and P =0.038 respectively). To estimate the CTV, a margin of 13% ±14% and 23% ±27% must be chosen for long and short diameter of tumor BV maps respectively. Conclusion: The BV map from 64-slice spiral CT perfusion imaging might to have the ability to delineate the volume target of brain tumor.关键词
体层摄影术/X线计算机/灌流/脑肿瘤/放射疗法/放射疗法/适形Key words
Tomography/ X-ray Computed/ Perfusion/Brain Neoplasms /Radiation Therapy/ Radiation Therapy/ Conformsl分类
医药卫生引用本文复制引用
孙昌进,郎锦义,王光辉,罗云秀,李涛,于金明,吕海波,李超,张德康,黄建鸣..64层灌注CT血容量图评价兔VX2脑瘤模型三维适形放疗解剖学靶区的实验研究[J].肿瘤预防与治疗,2012,25(4):215-219,5.基金项目
国家自然科学基金项目(项目号:C03031802) （项目号:C03031802）
