山东医药2012，Vol.52Issue(16)：4-6,3.
胃乐散对大鼠溃疡组织TXA2、PGI2 及COX-2含量的影响及意义
Effects of wei-le-san on TXA2, PGI2 and COX-2 in gastric ulcers of rats
摘要
Abstract
Objective To investigate the effects of wei-le-san on thromboxane A, (TXA2) , prostaglandin I2 (PGI2) and cyclooxygenase-2 ( COX-2) in gastric ulcers of rats, and probe its functional mechanism. Methods Forty-eight rats were randomly divided into normal group, model group, low dose of wei-le-san group, middle dose of wei-le-san group, high dose of wei-le-san group and ranitidine group. The rats of gastric ulcer were induced by glacial aceticacid. After drug treatment for 14 days, the rats gastric mucosa were collected to check the contents of TXB, and 6-Keto-PGF1α with ELISA, COX-2 by Western blot. Results Compared with control group, the levels of 6-Keto-PGF1α, COX-2 in model group were lower ( P < 0.05), the contents of TXB2, TXB2/6-Keto-PGF1α were higher (P < 0.05 ) , and wei-le-san elevated the level of 6-Keto-PGF1α in the rats gastric mucosa. Compared to the model group, the levels of 6-Keto-PGF1α, COX-2 in middle dose of wei-le-san group, high dose of wei-le-san group and ranitidine group increased (P <0. 05), and the contents of TXB,, TXB,/6-KetD-PGF1α decreased (P < 0.05). Conclusion Increasing the level of PGI2 and correcting the unbalance of TXA,/PGI2 may be one of the possible mechanisms of wei-le-san to cure gastric ulcer.关键词
胃乐散/血栓素A2/前列腺素I2/环氧合酶2/大鼠/胃溃疡Key words
wei-le-san/ thromboxane A2/ prostaglandin I2/ cyclooxygenase-2/ rats/ gastric ulcer分类
医药卫生引用本文复制引用
文国容,徐靖宇,刘雪梅,赵正兰,江义霞,谢睿,陈萍,余丽梅,庹必光..胃乐散对大鼠溃疡组织TXA2、PGI2 及COX-2含量的影响及意义[J].山东医药,2012,52(16):4-6,3.基金项目
国家自然科学基金资助项目(A-030) （A-030）
贵州省中医药管理局[黔中医药发(2009)79号]. （2009）
